isolation and identification of xanthotoxin (8-methoxypsoralen) from the fruits of heracleum persicum desf. ex fischer
نویسندگان
چکیده
linear furanocoumarins are toxic compounds synthesized by plants. these toxic natural products are usually found in the fruits of umbelliferae. heracleum persicum desf. ex fischer is an iranian aromatic medicinal plant from umbelliferae which their fruits are used as flavoring agent in food products. because of the wide usage of the fruits of h. persicum it was decided to do a phytochemical study on the fruits of the plant. the fruits of h. persicum were extracted with n-hexane and the extract was put on an open column chromatography. xanthotoxin (8-methoxypsoralen) was isolated from the fruits of the plant and the structure of the compound was elucidated by uv, ir, nmr and ms analyses. due to photosensitization caused by this compound, it is recommended to use low amounts of this plant in sensitive patients. however, only further quantitative studies on total furanocoumarins of the fruits can provide definite documents for any phototoxicological hazard.
منابع مشابه
Pharmacognostic and phytochemical investigation of Heracleum persicum Desf. ex Fischer
Background and objectives: Heracleum persicum aerial parts have been used in Iranian folk medicine for their therapeutic activities and as a spice and flavoring agent in Iranian foods and pickles. The present research was conducted to evaluate the pharmacognostic profile of H. persicum which will be useful in standardization for quality, purity, and sample ide...
متن کاملpharmacognostic and phytochemical investigation of heracleum persicum desf. ex fischer
background and objectives: heracleum persicum aerial parts have been used in iranian folk medicine for their therapeutic activities and as a spice and flavoring agent in iranian foods and pickles. the present research was conducted to evaluate the pharmacognostic profile of h. persicum which will be useful in standardization for quality, purity, and sample identification. methods: for quality c...
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Background: Heracleum persicum was introduced to Norway as an ornamental in the 1830′s. Towards the end of the 19th century, it started spreading outside gardens, later to become a frequent sight in the major towns and settlements of North Norway – and a veritable pest plant. During the last 100 years or so, a substantial ethnobotanical tradition related to the species has evolved, demonstratin...
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In the present work, the bioassay screening of the essential oil and various extracts of two plants including fruits of Heracleum persicum Desf. and rhizomes of Zingiber officinale Rosc. have been studied with brine shrimp test. There is only one report about cytotoxicity of H. sphondylium in literature and so H. persicum has been used as second selection. At first essentials oil and various ex...
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عنوان ژورنال:
research in pharmaceutical sciencesجلد ۲، شماره ۱، صفحات ۱۳-۰
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